Mechanically tunable coaxial electrospun models of YAP/TAZ mechanoresponse and IGF-1R activation in osteosarcoma

Current in vitro methods for assessing cancer biology and therapeutic response rely heavily on monolayer cell culture on hard, plastic surfaces that do not recapitulate essential elements of the tumor microenvironment. While a host of tumor models exist, most are not engineered to control the physic...

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Gepubliceerd in:Acta Biomater
Hoofdauteurs: Molina, Eric R., Chim, Letitia K., Salazar, Maria C., Mehta, Shail M., Menegaz, Brian A., Lamhamedi-Cherradi, Salah-Eddine, Satish, Tejus, Mohiuddin, Sana, McCall, David, Zaske, Ana Maria, Cuglievan, Branko, Lazar, Alexander J., Scott, David W., Grande-Allen, K. Jane, Ludwig, Joseph A., Mikos, Antonios G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7027943/
https://ncbi.nlm.nih.gov/pubmed/31542501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.actbio.2019.09.029
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