Mechanically tunable coaxial electrospun models of YAP/TAZ mechanoresponse and IGF-1R activation in osteosarcoma

Current in vitro methods for assessing cancer biology and therapeutic response rely heavily on monolayer cell culture on hard, plastic surfaces that do not recapitulate essential elements of the tumor microenvironment. While a host of tumor models exist, most are not engineered to control the physic...

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Pubblicato in:Acta Biomater
Autori principali: Molina, Eric R., Chim, Letitia K., Salazar, Maria C., Mehta, Shail M., Menegaz, Brian A., Lamhamedi-Cherradi, Salah-Eddine, Satish, Tejus, Mohiuddin, Sana, McCall, David, Zaske, Ana Maria, Cuglievan, Branko, Lazar, Alexander J., Scott, David W., Grande-Allen, K. Jane, Ludwig, Joseph A., Mikos, Antonios G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7027943/
https://ncbi.nlm.nih.gov/pubmed/31542501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.actbio.2019.09.029
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