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Inherited cardiac diseases, pluripotent stem cells, and genome editing combined—the past, present, and future

Research on mechanisms underlying monogenic cardiac diseases such as primary arrhythmias and cardiomyopathies has until recently been hampered by inherent limitations of heterologous cell systems, where mutant genes are expressed in noncardiac cells, and physiological differences between humans and...

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Bibliographic Details
Published in:Stem Cells
Main Authors: van den Brink, Lettine, Grandela, Catarina, Mummery, Christine L., Davis, Richard P.
Format: Artigo
Language:Inglês
Published: John Wiley & Sons, Inc. 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7027796/
https://ncbi.nlm.nih.gov/pubmed/31664757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.3110
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