Divalent cations promote TALE DNA-binding specificity

Recent advances in gene editing have been enabled by programmable nucleases such as transcription activator-like effector nucleases (TALENs) and CRISPR–Cas9. However, several open questions remain regarding the molecular machinery in these systems, including fundamental search and binding behavior a...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Cuculis, Luke, Zhao, Chuankai, Abil, Zhanar, Zhao, Huimin, Shukla, Diwakar, Schroeder, Charles M
Format: Artigo
Language:Inglês
Published: Oxford University Press 2020
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7026652/
https://ncbi.nlm.nih.gov/pubmed/31863586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1174
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