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Direct observation of TALE protein dynamics reveals a two-state search mechanism
Transcription activator-like effector (TALE) proteins are a class of programmable DNA-binding proteins for which the fundamental mechanisms governing the search process are not fully understood. Here we use single-molecule techniques to directly observe TALE search dynamics along DNA templates. We f...
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| Izdano u: | Nat Commun |
|---|---|
| Glavni autori: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Pub. Group
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4458887/ https://ncbi.nlm.nih.gov/pubmed/26027871 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8277 |
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