Phenotypic high-throughput screening platform identifies novel chemotypes for necroptosis inhibition

Regulated necrosis or necroptosis, mediated by receptor-interacting kinase 1 (RIPK1), RIPK3 and pseudokinase mixed lineage kinase domain-like protein (MLKL), contributes to the pathogenesis of inflammatory, infectious and degenerative diseases. Recently identified necroptosis inhibitors display mode...

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Pubblicato in:Cell Death Discov
Autori principali: Brito, Hugo, Marques, Vanda, Afonso, Marta B., Brown, Dean G., Börjesson, Ulf, Selmi, Nidhal, Smith, David M., Roberts, Ieuan O., Fitzek, Martina, Aniceto, Natália, Guedes, Rita C., Moreira, Rui, Rodrigues, Cecília M. P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7026080/
https://ncbi.nlm.nih.gov/pubmed/32123582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-020-0240-0
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