p53 Integrates Temporal WDR5 Inputs during Neuroectoderm and Mesoderm Differentiation of Mouse Embryonic Stem Cells

How ubiquitous transcription factors (TFs) coordinate temporal inputs from broadly expressed epigenetic factors to control cell fate remains poorly understood. Here, we uncover a molecular relationship between p53, an abundant embryonic TF, and WDR5, an essential member of the MLL chromatin modifyin...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Li, Qiang, Mao, Fengbiao, Zhou, Bo, Huang, Yuanhao, Zou, Zhenhua, denDekker, Aaron D., Xu, Jing, Hou, Sean, Liu, Jie, Dou, Yali, Rao, Rajesh C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7024586/
https://ncbi.nlm.nih.gov/pubmed/31940490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.12.039
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