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Natural genetic variation reveals key features of epigenetic and transcriptional memory in virus-specific CD8 T cells

Stable changes in chromatin states and gene expression in cells of the immune system form the basis for memory of infections and other challenges. Here, we used naturally occurring cis-regulatory variation in wild-derived inbred mouse strains to explore the mechanisms underlying long-lasting vs. tra...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: van der Veeken, Joris, Zhong, Yi, Sharma, Roshan, Mazutis, Linas, Dao, Phuong, Pe’er, Dana, Leslie, Christina S., Rudensky, Alexander Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7023907/
https://ncbi.nlm.nih.gov/pubmed/31027997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.03.031
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