Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein

Parkinson’s disease is a progressive neurodegenerative disorder characterised by the accumulation of misfolded α-synuclein in selected brain regions, including the substantia nigra pars compacta (SNpc), where marked loss of dopaminergic neurons is also observed. Yet, the relationship between misfold...

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Vydáno v:Acta Neuropathol Commun
Hlavní autoři: McKinnon, Chris, De Snoo, Mitchell L., Gondard, Elise, Neudorfer, Clemens, Chau, Hien, Ngana, Sophie G., O’Hara, Darren M., Brotchie, Jonathan M., Koprich, James B., Lozano, Andres M., Kalia, Lorraine V., Kalia, Suneil K.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7023783/
https://ncbi.nlm.nih.gov/pubmed/32059750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-0894-0
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