Systemic microbial TLR2 agonists induce neurodegeneration in Alzheimer’s disease mice

BACKGROUND: Accumulating data suggest a central role for brain microglia in mediating cortical neuronal death in Alzheimer’s disease (AD), and for Toll-like receptor 2 (TLR2) in their toxic activation. Amyloid deposition in preclinical AD is associated with microglial activation but not directly wit...

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Detaylı Bibliyografya
Yayımlandı:J Neuroinflammation
Asıl Yazarlar: Lax, Neta, Fainstein, Nina, Nishri, Yossi, Ben-Zvi, Ayal, Ben-Hur, Tamir
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2020
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7023749/
https://ncbi.nlm.nih.gov/pubmed/32059733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01738-z
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