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Chronic ethanol increases systemic TLR3 agonist-induced neuroinflammation and neurodegeneration
BACKGROUND: Increasing evidence links systemic inflammation to neuroinflammation and neurodegeneration. We previously found that systemic endotoxin, a TLR4 agonist or TNFα, increased blood TNFα that entered the brain activating microglia and persistent neuroinflammation. Further, we found that model...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
BioMed Central
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3412752/ https://ncbi.nlm.nih.gov/pubmed/22709825 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-130 |
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