Systemic LPS Causes Chronic Neuroinflammation and Progressive Neurodegeneration

Inflammation is implicated in the progressive nature of neurodegenerative diseases, such as Parkinson's disease, but the mechanisms are poorly understood. A single systemic lipopolysaccharide (LPS, 5 mg/kg, i.p.) or tumor necrosis factor alpha (TNFα, 0.25 mg/kg, i.p.) injection was administered...

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Hlavní autoři: Qin, Liya, Wu, Xuefei, Block, Michelle L., Liu, Yuxin, Breese, George R., Hong, Jau-Shyong, Knapp, Darin J., Crews, Fulton T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871685/
https://ncbi.nlm.nih.gov/pubmed/17203472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.20467
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