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Systemic microbial TLR2 agonists induce neurodegeneration in Alzheimer’s disease mice
BACKGROUND: Accumulating data suggest a central role for brain microglia in mediating cortical neuronal death in Alzheimer’s disease (AD), and for Toll-like receptor 2 (TLR2) in their toxic activation. Amyloid deposition in preclinical AD is associated with microglial activation but not directly wit...
Guardat en:
| Publicat a: | J Neuroinflammation |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7023749/ https://ncbi.nlm.nih.gov/pubmed/32059733 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01738-z |
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