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Pharmacophore-Directed Retrosynthesis Applied to Rameswaralide: Synthesis and Bioactivity of Sinularia Natural Product Tricyclic Cores

A Pharmacophore-Directed Retrosynthesis (PDR) strategy applied to rameswaralide provided simplified precursors bearing the common 5,5,6 (red) and 5,5,7 (blue) skeleton present in several cembranoid and norcembranoids from Sinularia soft corals. Key steps include a Diels-Alder lactonization organocas...

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Bibliographic Details
Published in:Org Lett
Main Authors: Truax, Nathanyal J., Ayinde, Safiat, Van, Khoi, Liu, Jun O., Romo, Daniel
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7023684/
https://ncbi.nlm.nih.gov/pubmed/31498642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.9b02713
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