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Pharmacophore-Directed Retrosynthesis Applied to Rameswaralide: Synthesis and Bioactivity of Sinularia Natural Product Tricyclic Cores
A Pharmacophore-Directed Retrosynthesis (PDR) strategy applied to rameswaralide provided simplified precursors bearing the common 5,5,6 (red) and 5,5,7 (blue) skeleton present in several cembranoid and norcembranoids from Sinularia soft corals. Key steps include a Diels-Alder lactonization organocas...
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| Published in: | Org Lett |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7023684/ https://ncbi.nlm.nih.gov/pubmed/31498642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.9b02713 |
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