Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

The metabolic characteristics of tumors present considerable hurdles to immune cell function and cancer immunotherapy. Using a glutamine antagonist, we metabolically dismantled the immunosuppressive microenvironment of tumors. We demonstrate that glutamine blockade in tumor-bearing mice suppresses o...

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Опубликовано в: :Science
Главные авторы: Leone, Robert D., Zhao, Liang, Englert, Judson M., Sun, Im-Meng, Oh, Min-Hee, Sun, Im-Hong, Arwood, Matthew L., Bettencourt, Ian A., Patel, Chirag H., Wen, Jiayu, Tam, Ada, Blosser, Richard L., Prchalova, Eva, Alt, Jesse, Rais, Rana, Slusher, Barbara S., Powell, Jonathan D.
Формат: Artigo
Язык:Inglês
Опубликовано: 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7023461/
https://ncbi.nlm.nih.gov/pubmed/31699883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav2588
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