Comparison of Various Cell Lines and Three-Dimensional Mucociliary Tissue Model Systems to Estimate Drug Permeability Using an In Vitro Transport Study to Predict Nasal Drug Absorption in Rats

Recently, various types of cultured cells have been used to research the mechanisms of transport and metabolism of drugs. Although many studies using cultured cell systems have been published, a comparison of different cultured cell systems has never been reported. In this study, Caco-2, Calu-3, Mad...

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Veröffentlicht in:Pharmaceutics
Hauptverfasser: Furubayashi, Tomoyuki, Inoue, Daisuke, Nishiyama, Noriko, Tanaka, Akiko, Yutani, Reiko, Kimura, Shunsuke, Katsumi, Hidemasa, Yamamoto, Akira, Sakane, Toshiyasu
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7023391/
https://ncbi.nlm.nih.gov/pubmed/31963555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12010079
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