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Melatonin Prevents Transforming Growth Factor-β1-Stimulated Transdifferentiation of Renal Interstitial Fibroblasts to Myofibroblasts by Suppressing Reactive Oxygen Species-Dependent Mechanisms

Accumulating evidence suggests that the pineal hormone melatonin displays protective effects against renal fibrosis, but the mechanisms remain poorly understood. Here, we investigate the effect of the pineal hormone on transdifferentiation of renal fibroblasts to myofibroblasts invoked by transformi...

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Detalhes bibliográficos
Publicado no:Antioxidants (Basel)
Main Authors: Kim, Jung-Yeon, Park, Jae-Hyung, Jeon, Eon Ju, Leem, Jaechan, Park, Kwan-Kyu
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022732/
https://ncbi.nlm.nih.gov/pubmed/31906396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox9010039
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