Impact of Suboptimal APOBEC3G Neutralization on the Emergence of HIV Drug Resistance in Humanized Mice

HIV diversification facilitates immune escape and complicates antiretroviral therapy. In this study, we take advantage of a humanized-mouse model to probe the contribution of APOBEC3 mutagenesis to viral evolution. Humanized mice were infected with isogenic HIV molecular clones (HIV-WT, HIV-45G, and...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Hernandez, Matthew M., Fahrny, Audrey, Jayaprakash, Anitha, Gers-Huber, Gustavo, Dillon-White, Marsha, Audigé, Annette, Mulder, Lubbertus C. F., Sachidanandam, Ravi, Speck, Roberto F., Simon, Viviana
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Genetic Diversity and Evolution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022346/
https://ncbi.nlm.nih.gov/pubmed/31801862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01543-19
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