Bardoxolone-Methyl (CDDO-Me) Suppresses Androgen Receptor and Its Splice-Variant AR-V7 and Enhances Efficacy of Enzalutamide in Prostate Cancer Cells

Androgen receptor (AR) signaling is fundamental to prostate cancer (PC) progression, and hence, androgen deprivation therapy (ADT) remains a mainstay of treatment. However, augmented AR signaling via both full length AR (AR-FL) and constitutively active AR splice variants, especially AR-V7, is assoc...

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Detalhes bibliográficos
Publicado no:Antioxidants (Basel)
Main Authors: Khurana, Namrata, Chandra, Partha K., Kim, Hogyoung, Abdel-Mageed, Asim B., Mondal, Debasis, Sikka, Suresh C.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022272/
https://ncbi.nlm.nih.gov/pubmed/31940946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox9010068
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