Nrf1 and Nrf2 Transcription Factors Regulate Androgen Receptor Transactivation in Prostate Cancer Cells

Despite androgen deprivation therapy (ADT), persistent androgen receptor (AR) signaling enables outgrowth of castration resistant prostate cancer (CRPC). In prostate cancer (PCa) cells, ADT may enhance AR activity through induction of oxidative stress. Herein, we investigated the roles of Nrf1 and N...

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Detalhes bibliográficos
Main Authors: Schultz, Michelle A., Hagan, Sharika S., Datta, Amrita, Zhang, Yiguo, Freeman, Michael L., Sikka, Suresh C., Abdel-Mageed, Asim B., Mondal, Debasis
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899380/
https://ncbi.nlm.nih.gov/pubmed/24466341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087204
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