Nrf1 and Nrf2 Transcription Factors Regulate Androgen Receptor Transactivation in Prostate Cancer Cells

Despite androgen deprivation therapy (ADT), persistent androgen receptor (AR) signaling enables outgrowth of castration resistant prostate cancer (CRPC). In prostate cancer (PCa) cells, ADT may enhance AR activity through induction of oxidative stress. Herein, we investigated the roles of Nrf1 and N...

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Autori principali: Schultz, Michelle A., Hagan, Sharika S., Datta, Amrita, Zhang, Yiguo, Freeman, Michael L., Sikka, Suresh C., Abdel-Mageed, Asim B., Mondal, Debasis
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899380/
https://ncbi.nlm.nih.gov/pubmed/24466341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087204
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