Nrf1 and Nrf2 Transcription Factors Regulate Androgen Receptor Transactivation in Prostate Cancer Cells

Despite androgen deprivation therapy (ADT), persistent androgen receptor (AR) signaling enables outgrowth of castration resistant prostate cancer (CRPC). In prostate cancer (PCa) cells, ADT may enhance AR activity through induction of oxidative stress. Herein, we investigated the roles of Nrf1 and N...

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Bibliografiske detaljer
Main Authors: Schultz, Michelle A., Hagan, Sharika S., Datta, Amrita, Zhang, Yiguo, Freeman, Michael L., Sikka, Suresh C., Abdel-Mageed, Asim B., Mondal, Debasis
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899380/
https://ncbi.nlm.nih.gov/pubmed/24466341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087204
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