CASZ1 induces skeletal muscle and rhabdomyosarcoma differentiation through a feed-forward loop with MYOD and MYOG

Embryonal rhabdomyosarcoma (ERMS) is a childhood cancer that expresses myogenic master regulatory factor MYOD but fails to differentiate. Here, we show that the zinc finger transcription factor CASZ1 up-regulates MYOD signature genes and induces skeletal muscle differentiation in normal myoblasts an...

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Vydáno v:Nat Commun
Hlavní autoři: Liu, Zhihui, Zhang, Xiyuan, Lei, Haiyan, Lam, Norris, Carter, Sakereh, Yockey, Oliver, Xu, Max, Mendoza, Arnulfo, Hernandez, Edjay R., Wei, Jun S., Khan, Javed, Yohe, Marielle E., Shern, Jack F., Thiele, Carol J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7021771/
https://ncbi.nlm.nih.gov/pubmed/32060262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14684-4
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