Pharmacokinetics and antiviral activity of cabotegravir and rilpivirine in cerebrospinal fluid following long-acting injectable administration in HIV-infected adults

BACKGROUND: Long-acting (LA) formulations of cabotegravir, an HIV integrase inhibitor, and rilpivirine, an NNRTI, are in development as monthly or 2 monthly intramuscular (IM) injections for maintenance of virological suppression. OBJECTIVES: To evaluate cabotegravir and rilpivirine CSF distribution...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Letendre, Scott L, Mills, Anthony, Hagins, Debbie, Swindells, Susan, Felizarta, Franco, Devente, Jerome, Bettacchi, Christopher, Lou, Yu, Ford, Susan, Sutton, Kenneth, Shaik, Jafar Sadik, Crauwels, Herta, D’Amico, Ronald, Patel, Parul
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7021098/
https://ncbi.nlm.nih.gov/pubmed/31873746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkz504
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