Platelet Membrane-Coated Nanoparticles Target Sclerotic Aortic Valves in ApoE(−/−) Mice by Multiple Binding Mechanisms Under Pathological Shear Stress

BACKGROUND: Aortic valve disease is the most common valvular heart disease leading to valve replacement. The efficacy of pharmacological therapy for aortic valve disease is limited by the high mechanical stress at the aortic valves impairing the binding rate. We aimed to identify nanoparticle coatin...

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Vydáno v:Int J Nanomedicine
Hlavní autoři: Yang, Hongbo, Song, Yanan, Chen, Jing, Pang, Zhiqing, Zhang, Ning, Cao, Jiatian, Wang, Qiaozi, Li, Qiyu, Zhang, Feng, Dai, Yuxiang, Li, Chenguang, Huang, Zheyong, Qian, Juying, Ge, Junbo
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove 2020
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7020933/
https://ncbi.nlm.nih.gov/pubmed/32103945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S224024
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