Twists or turns: stabilising alpha vs. beta turns in tetrapeptides

Protein–protein interactions involve hotspots as small as 4 sequential amino acids. Corresponding tetrapeptides have no structure in water. Here we report linking side chains of amino acids X and Z to form 24 cyclic tetrapeptides, cyclo-[XAAZ]-NH(2), and stabilise 14–18 membered rings that mimic dif...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Chem Sci
Päätekijät: Hoang, Huy N., Hill, Timothy A., Ruiz-Gómez, Gloria, Diness, Frederik, Mason, Jody M., Wu, Chongyang, Abbenante, Giovanni, Shepherd, Nicholas E., Fairlie, David P.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Royal Society of Chemistry 2019
Aiheet:
Chemistry
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7020788/
https://ncbi.nlm.nih.gov/pubmed/32110345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc04153b
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