TRIM21 Dysfunction Enhances Aberrant B-Cell Differentiation in Autoimmune Pathogenesis

TRIM21 is one of the autoantigens that reacts with an anti-SS-A antibody (Ab) present in patients with systemic lupus erythematosus (SLE) and Sjögren's syndrome. TRIM21 is thought to play a role in B-cell proliferation and apoptosis, among other activities. Here we examined a pathological role...

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Detalles Bibliográficos
Publicado en:Front Immunol
Autores principales: Kunishita, Yosuke, Yoshimi, Ryusuke, Kamiyama, Reikou, Kishimoto, Daiga, Yoshida, Koji, Hashimoto, Eijin, Komiya, Takaaki, Sakurai, Natsuki, Sugiyama, Yumiko, Kirino, Yohei, Ozato, Keiko, Nakajima, Hideaki
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7020776/
https://ncbi.nlm.nih.gov/pubmed/32117252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00098
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