Dysregulated heme oxygenase-1(low) M2-like macrophages augment lupus nephritis via Bach1 induced by type I interferons

BACKGROUND: Innate immunity including macrophages (Mϕ) in lupus nephritis (LN) has been gaining attention, but roles of Mϕ in LN remain uncertain. METHODS: Immunohistochemical staining was performed to determine CD68, CD163, heme oxygenase (HO)-1 (a stress-inducible heme-degrading enzyme with anti-i...

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Bibliographic Details
Published in:Arthritis Res Ther
Main Authors: Kishimoto, Daiga, Kirino, Yohei, Tamura, Maasa, Takeno, Mitsuhiro, Kunishita, Yosuke, Takase-Minegishi, Kaoru, Nakano, Hiroto, Kato, Ikuma, Nagahama, Kiyotaka, Yoshimi, Ryusuke, Igarashi, Kazuhiko, Aoki, Ichiro, Nakajima, Hideaki
Format: Artigo
Language:Inglês
Published: BioMed Central 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5894134/
https://ncbi.nlm.nih.gov/pubmed/29636091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-018-1568-1
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