GWAS-identified CCR1 and IL10 loci contribute to M1 macrophage-predominant inflammation in Behçet’s disease

BACKGROUND: Low C-C chemokine receptor 1 (CCR1) and interleukin (IL)-10 expression is associated with risk of Behçet’s disease (BD). The objective of the present study was to clarify the pathological roles of CCR1 and IL10 loci identified by previous BD genome-wide association studies (GWASs). METHO...

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Enregistré dans:
Détails bibliographiques
Publié dans:Arthritis Res Ther
Auteurs principaux: Nakano, Hiroto, Kirino, Yohei, Takeno, Mitsuhiro, Higashitani, Kana, Nagai, Hideto, Yoshimi, Ryusuke, Yamaguchi, Yukie, Kato, Ikuma, Aoki, Ichiro, Nakajima, Hideaki
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5998575/
https://ncbi.nlm.nih.gov/pubmed/29895319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-018-1613-0
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