Anti-PD-1 synergizes with cyclophosphamide to induce potent anti-tumor vaccine effects through novel mechanisms

Programmed death-1 receptor (PD-1) is expressed on T cells following TCR activation. Binding of this receptor to its cognate ligands, PD-L1 and PD-L2, down-regulates signals by the TCR, promoting T-cell anergy and apoptosis, thus leading to immune suppression. Here, we find that using an anti-PD-1 a...

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Veröffentlicht in:Eur J Immunol
Hauptverfasser: Mkrtichyan, Mikayel, Najjar, Yana G, Raulfs, Estella C, Abdalla, Maher Y, Samara, Raed, Rotem-Yehudar, Rinat, Cook, Larry, Khleif, Samir N
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7020689/
https://ncbi.nlm.nih.gov/pubmed/21710477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201141639
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