Pediatric patients with acute lymphoblastic leukemia generate abundant and functional neoantigen-specific CD8(+) T cell responses

Cancer arises from the accumulation of genetic alterations, which can lead to the production of mutant proteins not expressed by normal cells. These mutant proteins can be processed and presented on the cell surface by major histocompatibility complex molecules as neoepitopes, allowing CD8(+) T cell...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Zamora, Anthony E., Crawford, Jeremy Chase, Allen, E. Kaitlynn, Guo, Xi-zhi J., Bakke, Jesse, Carter, Robert A., Abdelsamed, Hossam A., Moustaki, Ardiana, Li, Yongjin, Chang, Ti-Cheng, Awad, Walid, Dallas, Mari H., Mullighan, Charles G., Downing, James R., Geiger, Terrence L., Chen, Taosheng, Green, Douglas R., Youngblood, Benjamin A., Zhang, Jinghui, Thomas, Paul G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7020562/
https://ncbi.nlm.nih.gov/pubmed/31243155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aat8549
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