DE NOVO EPIGENETIC PROGRAMS INHIBIT PD-1 BLOCKADE-MEDIATED T-CELL REJUVENATION

Immune-checkpoint blockade (ICB)-mediated rejuvenation of exhausted T cells has emerged as a promising approach for treating various cancers and chronic infections. However, T cells that become fully exhausted during prolonged antigen exposure remain refractory to ICB-mediated rejuvenation. We repor...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Ghoneim, Hazem E., Fan, Yiping, Moustaki, Ardiana, Abdelsamed, Hossam A., Dash, Pradyot, Dogra, Pranay, Carter, Robert, Awad, Walid, Neale, Geoff, Thomas, Paul G., Youngblood, Ben
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568784/
https://ncbi.nlm.nih.gov/pubmed/28648661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.06.007
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