H7N9 Influenza Virus Containing a Polybasic HA Cleavage Site Requires Minimal Host Adaptation to Obtain a Highly Pathogenic Disease Phenotype in Mice

Low pathogenic avian influenza (LPAI) H7N9 viruses have recently evolved to gain a polybasic cleavage site in the hemagglutinin (HA) protein, resulting in variants with increased lethality in poultry that meet the criteria for highly pathogenic avian influenza (HPAI) viruses. Both LPAI and HPAI vari...

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Publicat a:Viruses
Autors principals: Chan, Mable, Leung, Anders, Hisanaga, Tamiko, Pickering, Brad, Griffin, Bryan D., Vendramelli, Robert, Tailor, Nikesh, Wong, Gary, Bi, Yuhai, Babiuk, Shawn, Berhane, Yohannes, Kobasa, Darwyn
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7020020/
https://ncbi.nlm.nih.gov/pubmed/31948040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v12010065
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