Hemagglutinin-Neuraminidase Balance Influences the Virulence Phenotype of a Recombinant H5N3 Influenza A Virus Possessing a Polybasic HA(0) Cleavage Site

Although a polybasic HA(0) cleavage site is considered the dominant virulence determinant for highly pathogenic avian influenza (HPAI) H5 and H7 viruses, naturally occurring virus isolates possessing a polybasic HA(0) cleavage site have been identified that are low pathogenic in chickens. In this st...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Diederich, Sandra, Berhane, Yohannes, Embury-Hyatt, Carissa, Hisanaga, Tamiko, Handel, Katherine, Cottam-Birt, Colleen, Ranadheera, Charlene, Kobasa, Darwyn, Pasick, John
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621126/
https://ncbi.nlm.nih.gov/pubmed/26246579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01238-15
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