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Hemagglutinin-Neuraminidase Balance Influences the Virulence Phenotype of a Recombinant H5N3 Influenza A Virus Possessing a Polybasic HA(0) Cleavage Site
Although a polybasic HA(0) cleavage site is considered the dominant virulence determinant for highly pathogenic avian influenza (HPAI) H5 and H7 viruses, naturally occurring virus isolates possessing a polybasic HA(0) cleavage site have been identified that are low pathogenic in chickens. In this st...
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| Veröffentlicht in: | J Virol |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4621126/ https://ncbi.nlm.nih.gov/pubmed/26246579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01238-15 |
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