H7N9 Influenza Virus Containing a Polybasic HA Cleavage Site Requires Minimal Host Adaptation to Obtain a Highly Pathogenic Disease Phenotype in Mice

Low pathogenic avian influenza (LPAI) H7N9 viruses have recently evolved to gain a polybasic cleavage site in the hemagglutinin (HA) protein, resulting in variants with increased lethality in poultry that meet the criteria for highly pathogenic avian influenza (HPAI) viruses. Both LPAI and HPAI vari...

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Bibliographic Details
Published in:Viruses
Main Authors: Chan, Mable, Leung, Anders, Hisanaga, Tamiko, Pickering, Brad, Griffin, Bryan D., Vendramelli, Robert, Tailor, Nikesh, Wong, Gary, Bi, Yuhai, Babiuk, Shawn, Berhane, Yohannes, Kobasa, Darwyn
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7020020/
https://ncbi.nlm.nih.gov/pubmed/31948040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v12010065
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