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Patient-Derived Colorectal Cancer Organoids Upregulate Revival Stem Cell Marker Genes Following Chemotherapeutic Treatment

Colorectal cancer stem cells have been proposed to drive disease progression, tumour recurrence and chemoresistance. However, studies ablating leucine rich repeat containing G protein-coupled receptor 5 (LGR5)-positive stem cells have shown that they are rapidly replenished in primary tumours. Follo...

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Dettagli Bibliografici
Pubblicato in:J Clin Med
Autori principali: Engel, Rebekah M., Chan, Wing Hei, Nickless, David, Hlavca, Sara, Richards, Elizabeth, Kerr, Genevieve, Oliva, Karen, McMurrick, Paul J., Jardé, Thierry, Abud, Helen E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7019342/
https://ncbi.nlm.nih.gov/pubmed/31906589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcm9010128
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