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Patient-Derived Colorectal Cancer Organoids Upregulate Revival Stem Cell Marker Genes Following Chemotherapeutic Treatment

Colorectal cancer stem cells have been proposed to drive disease progression, tumour recurrence and chemoresistance. However, studies ablating leucine rich repeat containing G protein-coupled receptor 5 (LGR5)-positive stem cells have shown that they are rapidly replenished in primary tumours. Follo...

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Detalhes bibliográficos
Publicado no:J Clin Med
Main Authors: Engel, Rebekah M., Chan, Wing Hei, Nickless, David, Hlavca, Sara, Richards, Elizabeth, Kerr, Genevieve, Oliva, Karen, McMurrick, Paul J., Jardé, Thierry, Abud, Helen E.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7019342/
https://ncbi.nlm.nih.gov/pubmed/31906589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcm9010128
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