A cellular antidote to specifically deplete anti-CD19 chimeric antigen receptor–positive cells

Unintentional transduction of B-cell acute lymphoblastic leukemia blasts during CART19 manufacturing can lead to CAR19(+) leukemic cells (CARB19) that are resistant to CART19 killing. We developed an anti-CAR19 idiotype chimeric antigen receptor (αCAR19) to specifically recognize CAR19(+) cells. αCA...

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Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Ruella, Marco, Barrett, David M., Shestova, Olga, Perazzelli, Jessica, Posey, Avery D., Hong, Seok Jae, Kozlowski, Miroslaw, Lacey, Simon F., Melenhorst, J. Joseph, June, Carl H., Gill, Saar I.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2020
Sujets:
Immunobiology and Immunotherapy
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7019191/
https://ncbi.nlm.nih.gov/pubmed/31703119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019001859
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