The SIRT2-mediated deacetylation of AKR1C1 is required for suppressing its pro-metastasis function in Non-Small Cell Lung Cancer

Aldo-keto reductase family 1 member C1 (AKR1C1) promotes malignancy of Non-Small Cell Lung Cancer (NSCLC) by activating Signal Transducer and Activator of Transcription 3 (STAT3) pathway. However, how the pro-metastatic functions of AKR1C1 are switched on/off remains unknown. Methods: Immunoprecipit...

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Bibliographic Details
Published in:Theranostics
Main Authors: Zhu, Hong, Hu, Yan, Zeng, Chenming, Chang, Linlin, Ge, Fujin, Wang, Weihua, Yan, Fangjie, Zhao, Qinxin, Cao, Ji, Ying, Meidan, Gu, Yongchuan, Zheng, Lin, He, Qiaojun, Yang, Bo
Format: Artigo
Language:Inglês
Published: Ivyspring International Publisher 2020
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7019158/
https://ncbi.nlm.nih.gov/pubmed/32104503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.39151
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