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Normalization Methods on Single-Cell RNA-seq Data: An Empirical Survey

Data normalization is vital to single-cell sequencing, addressing limitations presented by low input material and various forms of bias or noise present in the sequencing process. Several such normalization methods exist, some of which rely on spike-in genes, molecules added in known quantities to s...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Lytal, Nicholas, Ran, Di, An, Lingling
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7019105/
https://ncbi.nlm.nih.gov/pubmed/32117453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2020.00041
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