Clonal Selection of a Novel Deleterious TP53 Somatic Mutation Discovered in ctDNA of a KIT/PDGFRA Wild-Type Gastrointestinal Stromal Tumor Resistant to Imatinib

The standard of care for the first-line treatment of advanced gastrointestinal stromal tumor (GIST) is represented by imatinib, which is given daily at a standard dosage until tumor progression. Resistance to imatinib commonly occurs through the clonal selection of genetic mutations in the tumor DNA...

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Dades bibliogràfiques
Publicat a:Front Pharmacol
Autors principals: Dalle Fratte, Chiara, Guardascione, Michela, De Mattia, Elena, Borsatti, Eugenio, Boschetto, Roberta, Farruggio, Angelo, Canzonieri, Vincenzo, Romanato, Loredana, Borsatti, Rachele, Gagno, Sara, Marangon, Elena, Polano, Maurizio, Buonadonna, Angela, Toffoli, Giuseppe, Cecchin, Erika
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7019050/
https://ncbi.nlm.nih.gov/pubmed/32116712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00036
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