Identification of Novel Somatic TP53 Mutations in Patients with High-Grade Serous Ovarian Cancer (HGSOC) Using Next-Generation Sequencing (NGS)

Somatic mutations in TP53 are a hallmark of high-grade serous ovarian cancer (HGSOC), although their prognostic and predictive value as markers is not well defined. Next-generation sequencing (NGS) can identify novel mutations with high sensitivity, that may be repurposed as potential druggable anti...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Garziera, Marica, Cecchin, Erika, Canzonieri, Vincenzo, Sorio, Roberto, Giorda, Giorgio, Scalone, Simona, De Mattia, Elena, Roncato, Rossana, Gagno, Sara, Poletto, Elena, Romanato, Loredana, Sartor, Franca, Polesel, Jerry, Toffoli, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
Assuntos:
Case Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983728/
https://ncbi.nlm.nih.gov/pubmed/29783665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19051510
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