Clonal Selection of a Novel Deleterious TP53 Somatic Mutation Discovered in ctDNA of a KIT/PDGFRA Wild-Type Gastrointestinal Stromal Tumor Resistant to Imatinib

The standard of care for the first-line treatment of advanced gastrointestinal stromal tumor (GIST) is represented by imatinib, which is given daily at a standard dosage until tumor progression. Resistance to imatinib commonly occurs through the clonal selection of genetic mutations in the tumor DNA...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Dalle Fratte, Chiara, Guardascione, Michela, De Mattia, Elena, Borsatti, Eugenio, Boschetto, Roberta, Farruggio, Angelo, Canzonieri, Vincenzo, Romanato, Loredana, Borsatti, Rachele, Gagno, Sara, Marangon, Elena, Polano, Maurizio, Buonadonna, Angela, Toffoli, Giuseppe, Cecchin, Erika
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7019050/
https://ncbi.nlm.nih.gov/pubmed/32116712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00036
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