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Enhanced homologous recombination by the modulation of targeting vector ends

The field of genome editing was founded on the establishment of methods, such as the clustered regularly interspaced short palindromic repeat (CRISPR) and CRISPR-associated protein (CRISPR/Cas) system, used to target DNA double-strand breaks (DSBs). However, the efficiency of genome editing also lar...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hirotsune, Shinji, Kiyonari, Hiroshi, Jin, Mingyue, Kumamoto, Kanako, Yoshida, Kayo, Shinohara, Miki, Watanabe, Hitomi, Wynshaw-Boris, Anthony, Matsuzaki, Fumio
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018964/
https://ncbi.nlm.nih.gov/pubmed/32054870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58893-9
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