Enhanced homologous recombination by the modulation of targeting vector ends

The field of genome editing was founded on the establishment of methods, such as the clustered regularly interspaced short palindromic repeat (CRISPR) and CRISPR-associated protein (CRISPR/Cas) system, used to target DNA double-strand breaks (DSBs). However, the efficiency of genome editing also lar...

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Vydáno v:Sci Rep
Hlavní autoři: Hirotsune, Shinji, Kiyonari, Hiroshi, Jin, Mingyue, Kumamoto, Kanako, Yoshida, Kayo, Shinohara, Miki, Watanabe, Hitomi, Wynshaw-Boris, Anthony, Matsuzaki, Fumio
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018964/
https://ncbi.nlm.nih.gov/pubmed/32054870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58893-9
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