Novel Cassette Assay To Quantify the Outer Membrane Permeability of Five β-Lactams Simultaneously in Carbapenem-Resistant Klebsiella pneumoniae and Enterobacter cloacae

Poor penetration through the outer membrane (OM) of Gram-negative bacteria is a major barrier of antibiotic development. While β-lactam antibiotics are commonly used against Klebsiella pneumoniae and Enterobacter cloacae, there are limited data on OM permeability especially in K. pneumoniae. Here, w...

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Veröffentlicht in:mBio
Hauptverfasser: Kim, Tae Hwan, Tao, Xun, Moya, Bartolome, Jiao, Yuanyuan, Basso, Kari B., Zhou, Jieqiang, Lang, Yinzhi, Sutaria, Dhruvitkumar S., Zavascki, Alexandre P., Barth, Afonso L., Reeve, Stephanie M., Schweizer, Herbert P., Deveson Lucas, Deanna, Boyce, John D., Bonomo, Robert A., Lee, Richard E., Shin, Beom Soo, Louie, Arnold, Drusano, George L., Bulitta, Jürgen B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018653/
https://ncbi.nlm.nih.gov/pubmed/32047131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.03189-19
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