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Aging aggravates intervertebral disc degeneration by regulating transcription factors toward chondrogenesis
Osterix is a critical transcription factor of mesenchymal stem cell fate, where its loss or loss of WNT signaling diverts differentiation to a chondrocytic lineage. Intervertebral disc (IVD) degeneration activates differentiation of prehypertrophic chondrocyte-like cells and inactivates WNT signalin...
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| Publicado no: | FASEB J |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7018543/ https://ncbi.nlm.nih.gov/pubmed/31909538 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201902109R |
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