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Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration

BACKGROUND CONTEXT: Destruction of extracellular matrix (ECM) leads to intervertebral disc degeneration (IDD), which underlies many spine-related disorders. Matrix metalloproteinases (MMPs), and disintegrins and metalloproteinases with thrombospondin motifs (ADAMTSs) are believed to be the major pro...

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Hlavní autoři: Vo, Nam V., Hartman, Robert A., Yurube, Takashi, Jacobs, Lloydine J., Sowa, Gwendolyn A., Kang, James D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637842/
https://ncbi.nlm.nih.gov/pubmed/23369495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.spinee.2012.02.027
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