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Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction

The AAA protein Msp1 extracts mislocalized tail-anchored membrane proteins and targets them for degradation, thus maintaining proper cell organization. How Msp1 selects its substrates and firmly engages them during the energetically unfavorable extraction process remains a mystery. To address this q...

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Vydáno v:eLife
Hlavní autoři: Wang, Lan, Myasnikov, Alexander, Pan, Xingjie, Walter, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018516/
https://ncbi.nlm.nih.gov/pubmed/31999255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.54031
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