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Mitochondrial AAA‐ATPase Msp1 detects mislocalized tail‐anchored proteins through a dual‐recognition mechanism

The conserved AAA‐ATPase Msp1 is embedded in the outer mitochondrial membrane and removes mislocalized tail‐anchored (TA) proteins upon dysfunction of the guided entry of tail‐anchored (GET) pathway. It remains unclear how Msp1 recognizes its substrates. Here, we extensively characterize Msp1 and it...

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Publicat a:EMBO Rep
Autors principals: Li, Lanlan, Zheng, Jing, Wu, Xi, Jiang, Hui
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6446203/
https://ncbi.nlm.nih.gov/pubmed/30858337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201846989
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