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Mitochondrial AAA‐ATPase Msp1 detects mislocalized tail‐anchored proteins through a dual‐recognition mechanism

The conserved AAA‐ATPase Msp1 is embedded in the outer mitochondrial membrane and removes mislocalized tail‐anchored (TA) proteins upon dysfunction of the guided entry of tail‐anchored (GET) pathway. It remains unclear how Msp1 recognizes its substrates. Here, we extensively characterize Msp1 and it...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Li, Lanlan, Zheng, Jing, Wu, Xi, Jiang, Hui
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6446203/
https://ncbi.nlm.nih.gov/pubmed/30858337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201846989
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